As people become more aware of the abnormal immune phenomenon of “allergy”, many patients are able to diagnose “allergy” on their own. If you have an itchy nose, itchy eyes, sneezing, or even wheezing in spring and autumn, you will immediately think of “pollen allergy”, and if you sneeze when you pack clothes or bed sheets, you will think of “dust mite allergy”. What can you think of if you have asthma or runny nose or sneezing when you enter a damp house where no one has lived for a long time? Yes, “fungal allergy”. How do you come into contact with “fungus” in your daily life? ”Fungi” is almost everywhere, from the mushrooms we often eat, fungus, silver fungus, to the Chinese medicine of Ganoderma lucidum, from the yeast of the flour, to the wine of the species (Aspergillus, root mold), sauce and curd with the mold, red Aspergillus, from food, clothing placed in moisture mold, to cause disease ringworm, poisoning, cancer-causing Aspergillus, etc.. Second, “fungal” allergies have what performance? Like other allergens, our exposure to fungi can be divided into four ways: inhalation, ingestion, injection, contact. Inhalation such as: into the moldy house caused asthma, ingestion such as: eat mushroom stuffed dumplings abdominal pain, injection such as: general itching, some injections of fungal products after antibiotics caused by allergies, contact such as: contact with moldy wood after the itching of the skin. Like other allergies, “fungal” allergy can also induce systemic allergic reactions, causing shock and death in severe cases. How is “fungal allergy” diagnosed? According to the patient’s medical history and the characteristics of the disease, the clinical consideration of the existence of “fungal allergy” may be called “non-specific diagnosis”, after which it needs to be clarified by allergen examination, and only then the first step of specific diagnosis is achieved. The gold standard for confirming the diagnosis is the provocation test, which is to induce symptoms after the patient is exposed to the allergen again, and is generally not done as a routine clinical treatment. Fourth, what are the concerns of desensitization? After the diagnosis is confirmed, treatment should be considered. Desensitization is the only causal treatment for allergic diseases, so should “fungal allergy” be desensitized? We know that the first principle of medicine is to cause no harm, and the prerequisite for desensitization is the availability of safe and reliable desensitizing agents. Fungal allergens are very complex and there are cross-allergies to the same lineage of fungi, but there are also different antigenic determinants. Moreover, due to the complex genetic characteristics of fungi, different morphology and environmental impact, different culture conditions, medium composition, environmental temperature and humidity can cause the variation of fungal morphology, thus affecting their allergenicity, the preparation of stable and representative fungal allergen preparations is not easy. Moreover, there is no strict boundary between allergenic fungi and toxic fungi, and the safety of fungal preparations is also an issue of great concern to us. 5. Is it true that “fungal allergy” must not be desensitized? No. As the only causal treatment, desensitization is highly specific and cannot be replaced by other treatments. On balance, if the benefits are expected to outweigh the risks, “fungal desensitization” can be safely used if the source of the preparation is reliable in a professional institution. This is because: first, the allergen preparation process requires a degreasing process that removes the fat-soluble fungal toxins, while the water-soluble portion contains minimal toxicity. Second, the last step of allergen preparation, are required to conduct animal toxicity tests, the dosage is hundreds of thousands of times higher than the clinical dosage, so the current clinical application of fungal allergens is considered safe.