The cause of vaginal itching and pain varies greatly. If a woman is suffering from itching and pain due to ulceration of the vagina caused by mycosis fungoides, she should first take oral fluconazole capsules and wash her vulva with sodium bicarbonate or take a sitz bath, and use clotrimazole suppositories or nifurtimox vaginal soft capsules for symptomatic vaginal application. However, if a woman is suffering from itching and pain due to trichomoniasis, she should take oral tinidazole tablets and use metronidazole suppositories for vaginal medication and, if necessary, apply erythromycin ointment to the ulcers on the vaginal wall for pain relief.