Fat grain is a pinhead-sized white bump on human skin. Fat grain on the face is mainly caused by cornu rashes, sweat duct tumors, acne, etc., which need to be treated reasonably according to different etiologies, using drugs, physical, surgical and other methods. 1. Corns: small cysts located in the dermis, which can be divided into primary and secondary corns, in which primary corns begin to appear from the newborn period, with the growth of age, the damage can subside on its own; and secondary corns are mainly caused by inflammation of the skin and damage to the sweat ducts. It can be avoided by applying topical retinoic acid drugs such as adapalene gel and retinoic acid cream to reduce skin keratinization, and avoiding the increase of milia; after local disinfection, the epidermis can be punctured with a needle, so as to don’t take out the yellowish-white granules, laser ablation and electrodesiccation can be used as the treatment choices as well. 2. Sweat duct tumor: it belongs to sweat gland tubular tumor-like lesion, which is mainly considered to be related to endocrine abnormality and other factors. Sweat duct tumors generally do not require special treatment. If they affect the appearance, they can be removed by physical methods such as freezing, electrocoagulation and photoelectric treatment. 3. Acne: In addition, acne can also lead to the appearance of fat grains on the face, is a kind of hair follicle sebaceous gland conduit blockage caused by non-inflammatory papules. Can be applied externally with retinoids such as adapalene gel, tazarotene gel, etc., which can help dissolve and discharge acne; followed by photodynamic, laser and other aesthetic means of removal. Since each patient’s condition is different, it is recommended that patients consult a doctor in a timely manner, take medication as prescribed by the doctor, and adopt appropriate methods of treatment under the doctor’s guidance.