Normally, pregnant women should avoid douching vaginally, but if the diagnosis of vaginitis in pregnancy and other diseases, the need for vaginal placement of drugs, can be carried out under the guidance of a doctor. Pregnant women blindly vaginal douche may cause the following adverse effects: 1, vaginal inflammation: under normal circumstances, Lactobacillus as the dominant vaginal flora, can maintain a weakly acidic environment in the vagina and inhibit the propagation of other pathogenic bacteria, so the vagina has the ability to self-cleaning. And pregnant women frequent vaginal douching can destroy the weakly acidic environment in the vagina, and may lead to vaginal flora dysbiosis and vaginitis. In addition, when pregnant women have factors such as the opening of the mouth of the uterus, vaginal douche easier to enter the uterine cavity, douche mixed with vaginal pathogenic bacteria into the uterine cavity, may lead to the uterine cavity and even pelvic retrograde infections; 2, preterm labor and preterm miscarriage: douche leads to vaginal flora disorders, opportunistic pathogens may be caused by cervical and uterine infections upward, inducing miscarriage. Late pregnancy pregnant women vaginal douching can stimulate vaginal muscle contraction, inducing contractions, which in turn induces preterm labor.