The prognosis for a large brainstem hemorrhage is generally poor, with the final outcome mostly ending in death. If the brainstem hemorrhage is large, first of all, active life support must be provided. The first priority of life support is to keep the airway open, mainly with ventilator assisted ventilation. Due to the extremely unstable circulation in brainstem bleeding, even if the blood pressure is high in the early stage, antihypertensive drugs should not be used easily. Because for brainstem hemorrhage, if antihypertensive drugs are used, once the blood pressure drops in the later stage, it will be difficult to rise again. Therefore, caution must be needed in the use of antihypertensive drugs. Secondly, active prevention and treatment should be carried out for related complications, such as lung infection, urinary tract infection, and deep vein thrombosis of the lower limbs. At the same time, nutritional support needs to be enhanced.