A painful wart is considered to be caused by infection with the human papilloma virus, which may be caused by local bacterial infection due to squeezing or scratching of the affected area. In this case, the patient may use appropriate anti-inflammatory oral medications and topical medications for relief and treatment. It is mostly seen that oral azithromycin tablets or doxycycline can strengthen the anti-bacterial infection and anti-inflammatory treatment, while topical application of Revnor solution, or rinsing with diluted potassium permanganate solution, and then application of anti-inflammatory creams such as clindamycin phosphate gel and compound polymyxin B ointment for treatment, most patients can have their symptoms reduced or even cured. In addition to medication, patients should try to avoid drinking alcohol after using medication to avoid stimulating the stomach, producing adverse reactions and affecting the efficacy of the medication. They can consume more protein-rich and vitamin-rich foods such as meat, eggs and milk to promote skin healing.