Shortness of breath and tightness of chest when eating may be related to heart disease, digestive disease, respiratory disease, etc., and need to be treated with medication and surgery. 1. For heart diseases, such as coronary heart disease, we need to take aspirin and other antiplatelet drugs, atorvastatin or benzapentadiene and other lipid-lowering drugs, isosorbide nitrate and other nitrate drugs, etc.; according to the specific conditions, we can perform percutaneous coronary intervention and coronary artery bypass grafting. 2. For digestive diseases, such as reflux esophagitis, oral omeprazole and other proton pump inhibitors, domperidone and other pro-dynamic drugs as prescribed by the doctor; if the conservative treatment is ineffective, the feasibility of anti-reflux surgery. 3. For respiratory diseases, such as chronic obstructive pulmonary disease, bronchodilators such as ipratropium bromide and inhaled glucocorticoids such as budesonide can be applied, and antibiotics such as amoxicillin can be added if the infection is combined. Specific drugs need to be taken in accordance with medical advice. It is recommended that people who have chest tightness and shortness of breath as soon as they eat go to the hospital in a timely manner to clarify the cause of the disease and standardize the treatment under the guidance of the doctor in order to avoid delaying the condition.