Renal colic is a common urological emergency that requires urgent treatment, and careful identification with other acute abdominal conditions is noted before applying drugs. At present, there are more drugs to relieve renal colic, and each place can apply drugs flexibly according to their own conditions and experience. 1, non-steroidal analgesic and anti-inflammatory drugs: commonly used drugs such as diclofenac sodium and indomethacin, which can inhibit the biosynthesis of prostaglandins in the body and reduce the sensitivity of nociceptive nerve endings to pain-causing substances, and have a moderate analgesic effect. 2, opioid analgesics: opioid receptor agonists, acting on the opioid receptors of the central nervous system, can relieve pain, with strong analgesic and sedative effects. Opioids should not be used alone in the treatment of renal colic, and generally need to be used together with atropine, 654-2 and other antispasmodic drugs. 3, antispasmodics: ① M-type choline receptor blockers, commonly used drugs include atropine sulfate and 654-2, which can relax ureteral smooth muscle and relieve spasm. ② Progesterone can inhibit the contraction of smooth muscle and relieve spasm, which has certain efficacy in pain relief and stone removal; ③ Calcium ion blockers, which have certain effect on relieving renal colic; ④ α-blockers (tamsulosin), some recent clinical reports at home and abroad show that α-blockers have certain effect in relieving ureteral smooth muscle spasm and treating renal colic. However, its exact efficacy remains to be observed in more clinical observations. In addition, acupuncture stimulation also has the effect of relieving spasm and relieving pain.