Intussusception is the most common acute abdominal disease in infancy, which is an intestinal obstruction caused by a part of the intestinal tube and its corresponding mesentery snapping into the adjacent intestinal cavity. The incidence is more than 60% within 1 year of age, with a peak incidence in infants aged 4 to 10 months, and the incidence decreases with age after 2 years of age, and is extremely rare after 5 years of age. The ratio of male to female is 2 to 3:1, with more boys than girls. From 1982 to 1985, we treated 927 cases of pediatric acute intussusception, including 643 male cases and 284 female cases, with a male to female ratio of 2.26:1. The disease can occur at all ages, and is most common in infants, with 854 cases within 2 years of age, of which more than half (55%) were 4 to 10 months old. The youngest age is 2 months. Intussusception can occur throughout the year, with the greatest incidence in late spring and early summer (March to May), probably related to upper respiratory tract infection and lymphadenovirus infection. Summer and winter are the next most common, and autumn (September to November) is less common. The incidence of pediatric acute intussusception in China is higher than that in Europe and the United States. The majority of intussusception is primary intussusception, the etiology of the disease is still unclear, may be related to the following factors: 1, dietary changes. Infants in the postnatal period of 4 to 10 months, it is to add complementary foods and increase the amount of milk, is also the peak of the incidence of intussusception. Because the infant’s intestine cannot immediately adapt to the stimulation of the changed food, causing intestinal dysfunction, resulting in a section of the intestinal tube into another section of the intestinal cavity caused by intussusception. 2. Anatomical factors in the ileocecal region. About 95% of infants with intestinal entrapment are ileocecal, and 90% of infants have a lip-like ileocecal flap convex into the cecum, which is more than 1cm long, plus the rich lymphatic tissue in this area, which is easily stimulated by inflammation or food to cause congestion, edema, hypertrophy, and intestinal peristalsis easily push the ileocecal flap forward and pull the intestinal tube to form entrapment. In 1955, Kiellen first isolated adenovirus in the mesenteric lymph nodes and thought it might be an important factor causing intussusception. Chinese Medical University reported that adenovirus was isolated from lymph nodes in 4 out of 37 cases of acute intussusception, and adenovirus was also isolated from stool and pharyngeal culture in 1 case, and the positive rate of virus isolation was 21.62%, and lymphatic follicular hyperplasia was seen on pathological lymph node examination in positive cases. 4, intestinal cramps and autonomic factors. Due to a variety of food, inflammation, diarrhea, bacteria or parasitic toxins stimulate the intestinal tract to produce spasm, so that the intestinal peristaltic function rhythm disorder or retroperistalsis and cause intestinal loop. 5, genetic factors. In recent years, it has been reported that there is a family history of intussusception.