Black nevus on glans mostly represents benign proliferation of melanocytes, and a few cases are seen in various glans inflammation caused by infection. Most of the nevus on glans is related to congenital genetics and development, and also has some relationship with poor local vascular reflux, if accompanied by redness, swelling, itching and other clinical manifestations, we should consider the factors of infection. Most of the glans nevus is benign, no need to deal with it in daily life if there is no other abnormal feeling. If the nevus is too large and affects sexual life, then laser can be considered for elimination. If in addition to the glans nevus, the glans also has itching, burning sensation, accompanied by erythema, papules, ulceration, oozing, erosion and other clinical manifestations, it may be due to trichomonas glans, circumscribed ulcerative glans, acute superficial glans, Candida albicans glans and other causes. In addition, we should pay attention to the patient’s glans to observe whether this nevus on the glans will increase rapidly, or accompanied by itching and pain, if the nevus increases progressively, it is recommended that surgical treatment and pathologic examination. It is recommended to reduce the intake of high-fat and high-sugar food, participate in social activities and physical exercise, and pay attention to local hygiene. It is recommended to consult a doctor as soon as possible for a clear diagnosis of the nevus on the glans, and handle it as soon as possible according to different situations.