Zhi Bai Di Huang Wan is a classic formula for the treatment of yin deficiency and fire, hot flashes and night sweats, dry mouth and sore throat, tinnitus and seminal emission, and short urine. Adverse reactions and contraindications are not clear, indicating that this medicine has a good safety profile. However, in daily life, it should be noted that: 1. pregnant women should take it with caution; 2. it is not suitable for patients with deficiency cold disease; 3. it should not be taken at the same time with cold and flu medicine; 4. it is prohibited for those who are allergic to the drug, and it should be used with caution for those with allergies. It is also used to nourish the liver and kidneys. Yam has the function of strengthening the spleen and nourishing the spleen-yin, and also has the power to strengthen the kidneys. Zhi Bai Di Huang Wan is mainly a tonic to achieve the co-regulation of the three yin of the liver, kidney and spleen. It is commonly used in clinical practice to treat senile vaginitis, women’s menopausal syndrome, recurrent mouth ulcers, and habitual constipation without adverse reactions and with good efficacy. Although Zhi Bai Di Huang Wan is a proprietary Chinese medicine with a high safety level, it should be remembered that “medicine is poisonous” and should not be used indiscriminately. For specific use, please refer to the doctor’s consultation for clinical guidance.