There are many types of skin diseases, which are also more common in our daily life, but we avoid talking about them if they involve the genital organs instead. In the following, we will explain chancre-like pyoderma, which is a relatively common type of infectious skin disease that occurs in the external genitalia and other areas and is clinically characterized by button-shaped superficial ulcers. It is a hard chancre-like lesion appearing on the face or genitalia in children or adults. it was first described by Hoffman in 1934. three cases were reported by Frain-Bell in 1957, who suggested that coagulase-positive Staphylococcus aureus might be the cause. However, other bacteria such as atypical acid-resistant bacilli, Escherichia coli or viruses cannot be excluded. In the following, we will introduce the alterations through three aspects: symptoms and signs, related tests and treatment measures. (I) Signs and symptoms Generally occur in adults, often on the face, especially near the eyes, and have also been reported in the genital area. The initial papules and pustules gradually expand and break down to form superficial ulcers like syphilis chancre, round or oval, about 1-4 cm in diameter, dark red and shiny, with more or less plasma secretions on the base of the ulcers, sometimes with yellow pus scabs. The lesions are mostly solitary, without conscious symptoms, and the nearby lymph nodes are enlarged and have pressure pain. The duration of the disease is from 2 weeks to several months, usually 4-8 weeks, leaving superficial scarring after healing, which can recur. Dark-field examination for spirochetes and syphilis serologic test are negative. (B) Histopathology: The entire epidermis shows an inflammatory reaction, which is filled with lymphocytes, plasma cells, fibroblasts and mast cells, and may also have eosinophils. Specific staining for fungi and mycobacteria is negative. Except for Staphylococcus aureus, which can be cultured, the culture of other fungi or viruses is negative, and no syphilis spirochete or syphilis seronegative has been found. (3) Treatment 1. Western medical therapy (1) Treatment Antibiotics sensitive to S. aureus can be tried. Because of the self-limiting course of the disease, it is difficult to evaluate the efficacy. (2) Prognosis The skin lesions may remain unchanged for 1 to 2 weeks, and then heal quickly to form a scar. The course of the disease is self-limiting, usually 4 to 8 weeks. 2. Commonly used drugs (1) Ciprofloxacin hydrochloride cream Broad-spectrum antibacterial drug. It is used to treat impetigo, folliculitis and other purulent skin infections. For external use, apply the appropriate amount to the affected area 2~3 times a day or as prescribed by the doctor. According to the above, we can learn that the main medication measures still lies in the systemic and local use of antibiotics. The disease itself is not scary, what is scary is the deterioration of the disease because we delay the best time for treatment. In the hospital, it is the doctor’s duty to save lives, while the patient should be seen in time.