Many diseases can cause polyhydramnios and polyuria, and diabetes is just one of them. Elevated blood glucose and increased urine glucose lead to osmotic diuresis, which manifests as more urination and more drinking.
Other diseases that can cause osmotic diuresis are: adrenocortical and renal tubular diseases that can cause hypokalemia and hyperkalemia, including primary aldosteronism, Cushing’s syndrome, congenital adrenocortical hyperplasia with potassium loss, and Bartter’s syndrome, Gitelman’s syndrome, and Liddle’s syndrome.
Diseases that can cause hypercalcemia and hypercalcemia: hyperparathyroidism or certain malignancies such as bone cancer, multiple myeloma, metastatic bone cancer, monocytic leukemia and Paget; solute diuresis can also occur when the body receives hypertonic fluids, dehydrating agents or larger amounts of isotonic solutions intravenously.
In addition, hypothalamic-pituitary hypofunction, inadequate secretion and release of antidiuretic hormone (ADH, AVP), or defective renal response to AVP can cause uremia, which may be characterized by polyhydramnios, polyuria, even tens of thousands of drinks, and a preference for cold drinks. Renal diseases, especially renal tubular diseases, lead to dysfunction of urine concentration, which can also be manifested as polyuria and polydipsia, with a marked increase in nocturia.