Drugs commonly used in the treatment of gout mainly include liver and kidney function injury, gastrointestinal injury, blood system injury, etc. Because of their different pharmacological mechanisms of different drugs, the corresponding adverse reactions are also different. 1. Non-steroidal anti-inflammatory drugs: mainly used for pain relief treatment of gouty arthritis. Commonly used are indomethacin, diclofenac, etc. Its common adverse reactions are gastrointestinal ulcers and bleeding, liver and renal function damage, cardiovascular system adverse reactions. 2. Allopurinol: mainly inhibit uric acid synthesis. Adverse reactions are mainly gastrointestinal reactions, skin rash, drug fever, elevated liver enzymes, etc. 3. Febuxostat: the main adverse reactions are hepatic impairment, diarrhea and so on. 4. Benzbromarone: the main adverse reactions are gastrointestinal reaction, rash, renal colic, granulocytopenia, etc. Rarely serious hepatotoxicity. Adverse effects of drugs for the treatment of gout are more, need to be taken under the guidance of a specialist physician, do not self-medication.