The causes of chest tightness after drinking may be alcohol allergy, coronary atherosclerosis and so on. 1. Alcohol allergy: If the body is allergic to alcohol after drinking, it produces an immune response to histamine and other immune factors released by immune cells, which can cause laryngeal edema, leading to poor breathing, which in turn affects the ventilation of the lungs, and so produces symptoms such as dyspnea and chest tightness. 2. Coronary atherosclerosis: this disease can lead to narrowing or blockage of blood vessels, so that the cardiomyocytes do not get sufficient blood supply and oxygen supply, which will lead to chest tightness. If you drink a lot of alcohol at this time, ethanol can be decomposed by the body dehydrogenase, generating a large number of acetaldehyde, which will stimulate vasodilation, accelerate the heart rate, increase myocardial oxygen consumption, aggravate the insufficient supply of oxygen to the heart, and still chest tightness. Chest tightness after drinking alcohol, should go to the hospital in time to receive professional medical treatment, do not delay.