The difference between psoriasis and flat warts is that although they both present with skin symptoms, they are different in terms of etiology, clinical manifestations and treatment. Psoriasis is a disease associated with genetic, environmental, and immune factors, and this typical clinical manifestation is scaly erythematous spots or plaques, limited or widely distributed. In addition, patients may also experience symptoms such as joint swelling, pain, and restricted movement. Treatment may include topical capotriol, tacrolimus ointment, and oral avermectin. Flat warts are a kind of disease caused by human papilloma virus (HPV) infection of the skin and mucous membranes, the surface of the skin of the patient can appear wart-like benign superfluous organisms, there may be a slight itching, the treatment can be used externally with salicylic acid, imiquimod ointment, but also through the frozen, microwave treatment. The psoriasis and flat warts patients, it is recommended to consult a professional doctor to identify, and follow the doctor’s instructions for treatment.