Nephrogenic edema, seen in all types of nephritis and nephropathy. The corresponding treatment is mainly to actively diagnose and treat the primary disease. And salt and water intake should be limited, if the edema is severe, diuretics can be tried for some diuretic dehydration treatment. If the kidney disease is more serious, patients who have been on peritoneal dialysis or hemodialysis should strengthen ultrafiltration to reduce edema and regulate the imbalance of water-sodium balance. The mechanism of nephrogenic edema is mainly caused by a variety of factors, including decreased renal excretion of water and sodium leading to water and sodium retention, increased extracellular fluid, and increased capillary hydrostatic pressure leading to nephrogenic edema. In addition, hypoproteinemia due to large amounts of proteinuria and ischemia of the renal parenchyma due to disorders of renal function, and decreased production of prostaglandins in the kidneys can aggravate the corresponding water-sodium retention. The symptoms of edema can progress from morning facial edema in the early stages of the disease to generalized edema. Specific treatment should start with reducing sodium retention. In conclusion, if the imbalance of water-sodium balance in nephrogenic edema causes a serious condition, and the edema does not subside, and if conventional treatment methods are ineffective, dialysis treatment should be urgently repeated to prevent further damage to the corresponding target organs.