Genital warts, also known as condyloma acuminata and venereal warts, are caused by the human papilloma virus (HPV), which occurs mainly in the anal genital area. It can be contracted through sexual contact or indirect contact with contaminated clothing. l0 on 6, 2008, the German scientist Chur? On October 6, 2008, German scientist Chur Housen was awarded the 2008 Nobel Prize in Physiology/Medicine for his major research discovery on human papillomavirus – “Human papillomavirus causes cervical cancer”. Papillomaviruses are small, envelope-free DNA viruses belonging to the family Papillomaviridae that infect the skin and mucosal epithelial tissue of humans and many advanced vertebrates, causing warts and even malignant tumors in the skin and mucous membranes. Papillomaviruses of different genera have strict species restriction and do not cross-infect between species, and have strict tissue restriction, i.e., they can only establish infection and complete the viral life cycle in the epithelial tissue of the corresponding species. Thus HPV is difficult to establish animal models and to obtain viral particles in in vitro culture, limiting HPV-related research. To date, the virus is still not amenable to effective tissue culture. Currently, 118 types of HPV have been isolated and identified, of which 2/3 are dermatophilic HPV and 1/3 are mucosalophilic. The most common lesions of dermatophilic HPV infecting human epithelial tissues are skin warts, including common warts, flat warts, plantar warts, etc. Skin warts are usually benign proliferations of epidermal tissues and heal well, with some lesions resolving on their own within 2 years, but in a few cases lasting for a long time. Mucosal HPV mainly infects the mucosal epithelium of the genitourinary tract, perineum, and oropharynx, and induces lesions such as various warts, squamous epithelial heterogeneous hyperplasia, and malignant tumors. About 40 species of mucosal HPV have been isolated and identified so far, of which 2/3 are high-risk types and the remaining 1/3 are low-risk types. According to the size of oncogenicity, HPV can be divided into 1. high-risk types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, 82 2. low-risk types: 6, 11, 13, 32, 34, 40, 42, 43, 44, 54, 61, 70, 72, 81, CP6108, of which HPV-6 and -11 infection is closely associated with the occurrence of more than 90% of genital warts and low-grade squamous epithelial proliferative lesions of the cervix. There are three intermediate or suspected high-risk types: 26, 53, and 66 4. There are also some types whose ability to induce benign or malignant lesions has not been determined: for example, 34, 57, and 83. The clinical manifestations of HPV infection are related to the viral type of infection, and mixed and sequential infections of multiple types are very common.