Trigeminal neuralgia is a terrible and persistent pain disorder that occurs in the face. The pain is paroxysmal, knife-like, fire-like, electric shock-like or tear-like pain, mostly triggered when the wind blows, washing face, brushing teeth, talking or eating, when the attack, patients often huddle on the ground holding their heads, or banging their heads against the wall, painful, so many people are frightened to mention this disease, “talking about the tiger”. First of all, let’s take a look at what the trigeminal nerve is. The trigeminal nerve is the fifth pair of cerebral nerves that emanates from the brain, and after penetrating the base of the skull, it forms a ganglion called the semilunar ganglion, from which three nerve branches, called the ophthalmic branch, maxillary branch and mandibular branch, respectively, innervate the ipsilateral facial skin sensation. The lesion of the trigeminal nerve causes transient, paroxysmal, recurrent electric shock-like or knife-like pain in its distribution area, partly accompanied by ipsilateral facial twitching. The disease is most common in the elderly, accounting for 70-80% of cases over 40 years of age, and more women than men. Trigeminal neuralgia is mostly secondary to viral infection or local chronic inflammation. According to the different causes, it can be divided into primary trigeminal neuralgia and secondary trigeminal neuralgia, among which primary trigeminal neuralgia is the most common. The three branches of the trigeminal nerve can develop separately or simultaneously, mostly on one side. If branch I develops, the pain is located on the ipsilateral brow arch, frontal area, temporal area, and sometimes may spread to the ipsilateral top; if branch II develops, the pain is located on the ipsilateral zygomatic area, frontal area of ear, nasal wing, maxilla, and the pain attack is easily triggered when touching the upper gum, nasal wing and corner of mouth; if branch III develops, the pain is located on the ipsilateral lower jaw, lower gum and lower lip, and the pain attack is easily triggered when touching the lower lip or lower gum. Trigeminal neuralgia is a very persistent disease that is generally poorly treated and prone to recurrence. In recent years, there are more effective drugs and methods in the treatment of this disease, which are briefly discussed below. 1, should be preferred to drug therapy. The commonly used drugs are carbamazepine, phenytoin sodium, but also with the application of sedative and analgesic drugs such as Valium, traditional Chinese medicine and vitamin B1, B12. In the early stage of the disease, the short duration of the disease, light patients can be used, but for those who are not effective should not rely on long-term drug therapy, because of its more side effects. 2.Nerve block therapy: It is the most commonly used and effective method to treat trigeminal neuralgia. Different nerve block methods are used according to the location and scope of trigeminal neuralgia. Because of the high requirement of puncture technique, it must be operated by experienced pain physicians, dentists or neurosurgeons. In the early stage, local anesthetics plus corticosteroids plus vitamins are used to perform local nerve blocks. In stubborn cases, nerve-destroying drugs such as anhydrous ethanol and phenol glycerin can be used for injection. 3.Surgical therapy: It should be said that it is the most effective method to treat trigeminal neuralgia, but it is not suitable for patients because of the large trauma, high cost, complications and sequelae. 4.Radiofrequency temperature-controlled thermal coagulation therapy: It is an emerging treatment method, which consists of a special puncture needle to the nerve trunk or semilunar ganglion to be treated, and thermal coagulation necrosis of the local nerve by radiofrequency. This method requires high equipment and is relatively expensive. 5, other therapies: such as X-ray knife, gamma knife, the efficacy is exact, but the equipment requirements are high and expensive.