Moles, scientifically called pigmented nevi, are benign neoplasms made up of nevus cells that are present in almost everyone and can occur all over the body. Pigmented nevi can be congenital, present at birth, and are usually relatively large with hair growth on them, and some congenital pigmented nevi are so large that they can cover half of the body. Of course most pigmented nevi occur later in life and often increase with age, often significantly during development, and their number is not directly related to physical health and are generally small. Many friends who have seen the movie “Do Not Disturb 2” are very worried that the moles on their bodies will become malignant. In fact, there is no need to worry too much about this. For yellow people, the majority of moles are benign, and only a very small number of moles can become malignant to melanoma, according to a statistic, the probability of occurrence is about one in 100,000. In contrast, the probability of moles becoming malignant is much higher in Caucasians. Repeated chronic irritation or improper treatment of pigmented moles (e.g., finger picking, scratching, needle picking, or chemical etching agents) over a long period of time may contribute to their malignant transformation. In addition, pigmented moles located in friction-prone areas, such as the soles of the feet, palms of the hands and vulva, may have a higher probability of malignant transformation than other areas. If a pigmented mole shows the following signals, you should be alert to the possibility of malignant transformation and go to a hospital for medical consultation in time. 1. The original mole increases significantly in a year, and its color deepens and brightens significantly. 2.The pigmentation of the original mole changes or becomes uneven, from brown to black, or from brown to black and brown spots. 3.The edges of moles become irregular or appear small satellite-like moles, or several moles fuse and the surface is uneven. 4.Pinprick-like pain, itching and burning sensation appear locally. 5.Moles are often inflamed, ulcerated, running, bleeding or crusted. Mole pigment can be removed by either surgery or laser. Surgical removal is generally quite thorough and has a very low recurrence rate, although of course there may be some scarring. In contrast, laser treatment is easy to perform, has a smaller scar and good cosmetic results, but has a higher recurrence rate than surgery. Laser and surgical removal of pigmented moles can each have their own advantages. It depends on the location of the mole and the condition of the mole for specific treatment. For moles that are irritated by friction for a long time or have the above-mentioned danger signs, surgical removal is preferred, combined with histopathological examination.