How statins are chosen depends on the level of cholesterol, the adverse effects of the drug and the patient’s health condition. The main effect of statins is to lower LDL cholesterol. Clinically, the main statins commonly used are atorvastatin, resuvastatin, simvastatin, pravastatin, fluvastatin and so on. Generally speaking, when the level of LDL cholesterol is high, strong statins, such as Rosuvastatin and Atorvastatin, should be used; and when the LDL cholesterol is mildly to moderately elevated, other medium to low potency statins, such as Simvastatin and Pravastatin, can be used. For elderly patients with other diseases, they may need to take multiple other medications at the same time, and pravastatin, which has a higher safety profile, may be used. For patients with renal insufficiency, when the glomerular filtration rate is less than 30mL/min, it is forbidden to take Rosuvastatin; for patients with severe renal insufficiency, it is forbidden to take fluvastatin. In terms of dosage, patients with renal insufficiency do not need to reduce the dosage of atorvastatin, while the dosage of Rosuvastatin, Simvastatin, Pravastatin, and Fluvastatin should be adjusted under the advice of a doctor. If you need to use lipid-lowering drugs, it is recommended to use them under the guidance of a professional doctor.