Renal dysfunction, also known as renal insufficiency, can be caused by a variety of reasons and requires comprehensive treatment. 1. Early diagnosis, effective treatment of primary diseases and removal of factors leading to deterioration of renal function should be carried out. Renal dysfunction is divided into primary renal insufficiency and secondary renal insufficiency. The former is mostly caused by glomerulonephritis, nephrotic syndrome, renal tuberculosis and other diseases, while the latter is mostly caused by hypertension, diabetes and other chronic diseases. Active treatment of primary kidney diseases, avoidance of nephrotoxic drugs, control of hypertension, hyperglycemia, hyperlipidemia and other risk factors can reduce further damage to the kidney, which is the prerequisite and basis for the treatment of renal insufficiency. 2, nutritional therapy: protein-limited diet is a key part of nutritional therapy, which can reduce the burden on the kidney and slow down the progress of the disease. Patients need to ensure adequate calorie intake while low salt, low protein and high quality protein diet. 3, renal dysfunction will lead to water-electrolyte disorders, anemia, hypertension and other symptoms, which in turn will aggravate renal failure, a vicious circle, so these complications should be prevented and treated in a timely manner. 4, the use of drugs to protect kidney function, such as urotropic pellets, alpha keto acid, etc., the specific usage needs to be used under the guidance of nephrologists. 5.Renal replacement therapy, when renal dysfunction is serious and starts to show uremia, renal replacement therapy should be started as soon as possible, including hemodialysis, peritoneal dialysis and kidney transplantation treatment. The condition is reversible when the symptoms of renal dysfunction are mild, but can develop into life threatening uremia when severe, early detection and early treatment can help a lot in disease prognosis.