Nocturnal episodes of paroxysmal atrial fibrillation can be treated with medications such as deacetyltrichoside, amiodarone, etc., and radiofrequency ablation can be used if medication is ineffective. Nocturnal episodes of paroxysmal atrial fibrillation refers to the short duration, irregular intermittent fibrillation of the atria, which often occurs at night, and manifests itself as short duration and intermittent palpitations, panic, dizziness, chest tightness and other symptoms, and can be treated with medication such as deacetylmorillonite, amiodarone, etc. If medication does not have an effect, and if medication is ineffective, radiofrequency ablation can be used. If medication is not effective and nocturnal episodes of paroxysmal atrial fibrillation have caused serious impact on the patient’s life, radiofrequency ablation can be given after examination by a physician. The above drugs should be taken under the guidance of a physician, and should not be used blindly.