What is ABO blood type disorder? There are four types of human ABO blood groups: A, B, O and AB. If the mother has O blood type and the father has A or B blood type, the fetus may have A or O (father’s A) and B or O (father’s B) blood types. If the mother and the fetus have different blood types, the anti-A or anti-B antibodies in the O mother may have a destructive effect on the fetus’ blood cells. This effect does not occur if the mother has a different blood type from the fetus. Blood group incompatibility also rarely occurs if the mother is of A, B or AB blood type. What is an RH blood type disorder? RH blood type is another classification system regarding blood type. Generally, Han Chinese tend to have RH positive blood type. If the mother is RH-negative and the father is RH-positive, the fetus will have an RH-positive blood type, which is different from the mother’s blood type. The RH negative blood mother must pay attention to the first pregnancy, when there are no RH antibodies in her body. As the number of pregnancies increases and the RH antibodies in the mother’s body increase, this hemolytic effect is enhanced and has a great impact on the fetus, which may lead to miscarriage, fetal death, fetal anemia, nuclear jaundice and other serious consequences. How should ABO blood group incompatibility be treated? ABO blood group incompatibility has little effect on the fetus and rarely results in fetal hemolysis, hepatosplenomegaly, kernicterus and other serious threats to fetal life. What should be done for recurrent miscarriage caused by RH blood group incompatibility? If the husband is RH-positive and the pregnant mother with RH blood group negative can be tested for antibody potency in the blood during pregnancy. If anti-D antibodies are not present, immunoglobulin D can be injected at 28 weeks of pregnancy and within 72 hours after delivery to prevent antibody production. If antibodies are present before pregnancy, antibody potency in the blood should be monitored at 16-20 weeks of gestation. If there is an abnormal increase, immunosuppressive drugs can be used early on. Monitor the fetus closely during pregnancy and do maternal plasma exchange or fetal intrauterine transfusion therapy if necessary.