Taking sorafenib body will lose weight, may be because of the gastrointestinal reaction caused by the drug, but also may be caused by the disease itself. Sorafenib is a kind of antitumor drug, which has certain therapeutic effect on hepatocellular carcinoma that cannot be operated or metastasized in distant places, and certain gastrointestinal toxic adverse reactions may occur after using the drug, such as decreased appetite, nausea, vomiting, dyspepsia, constipation, gastroesophageal reflux, dysphagia, and so on, which may lead to body wasting. In addition, it may also be caused by the disease itself, because malignant neoplastic disease is a chronic wasting disease, which itself may lead to the body’s chronic consumption, thus leading to body wasting. If the wasting of the body is too obvious when taking Sorafenib and accompanied by other uncomfortable symptoms, it is necessary to suspend the use of the drug and consult a doctor if necessary.