Long-term use of medications for coronary artery disease can have adverse effects such as bleeding, impaired liver and kidney function, and headaches. Patients with coronary heart disease need to take long-term oral aspirin, atorvastatin, isosorbide nitrate and other drugs, and some adverse reactions may occur in the process of taking drugs. Aspirin mainly inhibits platelet aggregation, the risk of bleeding may occur during the course of taking the drug, skin mucous membrane bleeding is the most common, serious can occur in the digestive tract, urinary tract, and even intracranial hemorrhage. It is contraindicated for aspirin allergy, aspirin-related asthma, active ulcers, and active bleeding. Atorvastatin mainly reduces blood lipids and inhibits cholesterol synthesis, the adverse effects of the drug include impaired hepatic and renal function, and rhabdomyolysis can also occur in a few patients. Allergy to the components of the drug, severe hepatic impairment, lactation is contraindicated in women during pregnancy. Isosorbide nitrate mainly expands coronary arteries, at the same time, it has a dilating effect on cerebral blood vessels, headache, palpitations and other adverse reactions can occur after taking the drug. It is forbidden for those who are allergic to the ingredients of the drug. Coronary heart disease patients in the process of taking drugs, pay attention to strengthen the monitoring of adverse drug reactions, symptoms are obvious to the hospital in a timely manner, under the guidance of the physician treatment.