Chest tightness is not a precursor of certain diseases, but when chest tightness occurs, it is necessary to exclude chest wall diseases, cardiovascular diseases, respiratory diseases, mediastinal diseases, gastroesophageal diseases, and so on, and the specific causes need to be analyzed in combination with other symptoms or auxiliary examinations. 1. Chest wall diseases: common diseases include acute dermatitis, herpes zoster, intercostal neuritis, multiple osteomyelitis, etc., whose clinical feature is that most of the chest tightness is related to respiration, and deep and big breaths can cause chest tightness to aggravate. 2. Cardiovascular diseases: common diseases include coronary heart disease, cardiomyopathy, heart valve disease, pericarditis, arrhythmia, heart failure, pulmonary artery embolism, etc., which are characterized by paroxysmal episodes or persistent aggravation of chest tightness accompanied by dyspnea. 3. Respiratory diseases: common diseases include pneumothorax, lung tumor, bronchitis, etc., which are characterized by chest tightness combined with respiratory symptoms, such as cough, sputum, hemoptysis and dyspnea. 4. Mediastinal diseases: common diseases include mediastinal inflammation, mediastinal tumor, etc. This group of diseases has no obvious specific symptoms, and some patients may have chest tightness, hoarseness, and decrease in pitch, which need to be combined with chest imaging to make a clear diagnosis. 5. Gastroesophageal diseases: common diseases include gastroesophageal reflux disease, esophageal tumors, etc., which are manifested as chest tightness accompanied by progressive dysphagia, retrosternal burning sensation, etc., and need to improve gastroscopy to make a clear diagnosis. When the symptoms of chest tightness, it is recommended to go to the hospital to improve the chest CT, electrocardiogram, cardiac enzymology, gastroscopy and other tests, in order to clarify the diagnosis, do not blindly treatment, so as not to delay the condition.