Lung cancer with fever may be caused by co-infection, fever caused by pleural effusion, cancer fever, etc. It is often treated with antibiotics, acetaminophen and other drugs. 1. Lung infection: Tumor causes patients’ immunity to be lowered, especially low white blood cells, which often causes fever due to infection. Patients with lung cancer combined with lung infection may suffer from pneumonia and bronchitis due to bacterial infection, which may cause fever, and can be treated with antibiotics such as penicillin and azithromycin. 2. Pleural effusion: Lung cancer with fever may be due to large amount of pleural effusion produced by lung cancer, if pleural effusion is not extracted in time, it will lead to fever when reabsorption of pleural effusion occurs, or pleural effusion may cause pleurisy and lead to fever, which should be treated with antibiotics such as penicillin, etc., and those who have pleural effusion should be treated with timely extraction of pleural effusion by thoracocentesis. 3. Cancer fever: Cancer fever is caused by pyrogen released from necrosis of cancer cells, which can be treated with naproxen, acetaminophen and other drugs. Lung cancer with fever is recommended to be treated under the guidance of specialized doctors and clinical pharmacists.