Methods: Remove necrotic tissue, pus moss and pus, rinse the wound with hydrogen peroxide and saline; build VSD foam into the shape of the wound and fill the incision, place two silicone drainage tubes outside the incision and close the surrounding skin edges tightly with a biological semi-permeable membrane for more than 5cm; connect one silicone drainage tube to the bedside center negative pressure drainage bottle for continuous suction, maintain the negative pressure at -80mmhg, and the other silicone tube connects to physiological saline 500ml for wound rinsing, 2 times/day to prevent small holes in the dressing and drainage tube blockage. The dressing was removed after 7-10 days of VSD and the infected incision wound was closed with wide adhesive tape. RESULTS: Infection was generally significantly controlled after 7-10 days of trauma drainage, pus moss within the trauma disappeared, exudation was significantly reduced, there was fresh granulation tissue growth, the incision was closed with wide adhesive tape, and the incision healed in 8-14 days. The whole healing time was significantly shortened compared with the traditional dressing change, and the patient’s hospital stay and cost were significantly reduced. Discussion: Compared with traditional drainage dressings, VSD applied to infected wounds has the following unique advantages: continuous negative pressure drainage ensures the patency of drainage; continuous negative pressure can significantly accelerate the contraction closure of the infected cavity and the closure of the infected wound. The use of antibiotics is reduced, and the number of drug changes is reduced to shorten the hospital stay, thus reducing hospitalization costs; the semi-permeable patch facilitates the observation of the wound and facilitates care. VSD is a very suitable and advantageous option for severe incisional infections after abdominal surgery.