Chest tightness and chest pain all day long may be due to coronary heart disease, pleurisy, tuberculosis, reflux esophagitis, cardiac neurosis, etc., which need to be treated with medication or surgery for the cause. 1. Coronary heart disease: Because of the formation of atherosclerotic plaques in the coronary arteries supplying blood to the heart, the lumen becomes narrowed and leads to myocardial ischemia, so there will be chest tightness and chest pain all day long. You can take aspirin, clopidogrel, resuvastatin, isosorbide nitrate and other medications, and can also be treated by coronary intervention with stents or coronary artery bypass graft surgery. 2. Pleurisy: chronic inflammatory reaction caused by long-term and repeated bacterial infection of pleura, so chest tightness and chest pain all day long. Penicillin, metronidazole, cefuroxime and other antibacterial drugs can be applied. 3. Tuberculosis: Mycobacterium tuberculosis infection causes specific immune response in the lungs, leading to destruction of lung tissues, chest tightness and chest pain, low-grade fever, night sweats, fatigue and other symptoms. Anti-tuberculosis drugs such as rifampicin, isoniazid, pyrazinamide and ethambutol can be taken for treatment. 4. Reflux esophagitis: gastric acid refluxes into the esophagus after the dysfunction of the lower esophageal sphincter, corroding the mucosa of the esophagus and causing chest tightness and chest pain all day long, accompanied by dysphagia, acid reflux and heartburn. You can take eplazole, ranitidine, domperidone, aluminum magnesium carbonate and other drugs for treatment. 5. Cardiac neurosis: exclude organic lesions, may be related to mental psychological factors, you can take alprazolam, haloperidol melittin and other sedative drugs. Pay attention to the examination and treatment under the guidance of the physician.