At present, there is no specific drug dedicated to lowering creatinine in the clinic. In order to reduce creatinine, it is necessary to actively treat the primary disease and improve renal function. You can orally take urethralin granules and renal failure capsules to excrete toxins and achieve the purpose of lowering creatinine. If the creatinine is elevated due to various chronic kidney diseases, it is necessary to apply drugs to reduce urinary protein and blood pressure, such as angiotensin-converting enzyme inhibitors captopril and enalapril, as well as angiotensin II receptor inhibitors such as valsartan and chloretin, which can help to promote the restoration of renal function, improve the glomerular filtration rate, and reduce creatinine. In addition, glucocorticosteroids such as methylprednisolone and immunosuppressants such as cyclophosphamide are also useful for the treatment of decreased glomerular filtration rate caused by autoimmune nephropathy. At the same time, you can also take oral urethane granules, renal failure capsules, medicinal charcoal tablets, etc. to expel toxins to achieve the purpose of lowering creatinine. All the above medications should be used under doctor’s guidance, avoid self-medication. Patients with elevated creatinine are advised to go to regular hospitals in time and receive standardized treatment under the guidance of doctors.