The hepatitis B virus has three important antigens: the surface antigen (HBsAg), which is the outer coat of the virus and was once called the “Australian antigen” because it was first discovered in Australia; the e antigen (HBeAg) and the core ( The e antigen (HBeAg) and the core (HBcAg) are both structures in the central part of the virus. These three antigens can stimulate the body to produce anti-HBs, anti-HBe and anti-HBc antibodies respectively. Since HBcAg is not easily detected in blood, when testing for hepatitis B virus, we can only test for HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc, so they are often referred to as “hepatitis B five” or “hepatitis B two-and-a-half”. The five indicators are often referred to as the “five hepatitis B tests” or “hepatitis B two-to-one”. In these five indicators, if HBsAg, HBeAg and anti-HBc indicators are positive, people often say hepatitis B “major three positive” infection; if HBsAg, anti-HBe and anti-HBc indicators are positive, people often say hepatitis B “minor three positive If the indicators of HBsAg, anti-HBe and anti-HBc are positive, it is often referred to as “small triple-positive” hepatitis B infection. Generally speaking, the e antigen (HBeAg) is a sign of hepatitis B virus replication. Therefore, a person with hepatitis B “major triple-positive” infection has active viral replication in the body, the viral gene (DNA) test is positive, and liver function may be abnormal; while the virus in the body of a person with hepatitis B “minor triple-positive” infection is in a relatively quiescent state, with less viral replication. The DNA test is negative, and liver function is mostly normal.