HPV is a sexually transmitted virus that is mainly transmitted directly through sexual intercourse, but can also be transmitted indirectly through contaminated underwear, bath towels, and urinals, etc. HPV infection is more common in young women aged 20 to 29. The HPV is a disease that has been found to be associated with the development of malignant tumors. Condyloma acuminatum: A papular vulvar lesion caused by human papilloma virus, which can also involve the vagina and cervix. It is associated with low-risk HPV types 6 and 11 and is mainly transmitted directly through sexual intercourse. The incubation period ranges from 3 weeks to 8 months. Clinical symptoms are not obvious and most patients are seen with vulvar redundancy. Some patients have vulvar pruritus, burning pain or bleeding after sexual intercourse, and lesions are more common in areas that are easily damaged during sexual intercourse. Cytological examination and pathological examination with the presence of excavated cells are characteristic changes of HPV infection and can lead to a clear diagnosis. There is no method to eradicate HPV, and treatment is based on the removal of lesions and improvement of symptoms, including drug, physical and local surgical treatment.