The conduction pathways associated with somatic movements outside the pyramidal system are collectively referred to as the extrapyramidal system, which is relatively old in germline occurrence and has the main function of regulating muscle tone, coordinating muscle movement, and maintaining postural posture. Extrapyramidal reactions (EPS) are the most common neurological adverse effects of traditional antipsychotics. There are four main types: 1. Acute dystonia: the earliest occurrence. Persistent tonic contraction of local muscle groups, presenting involuntary peculiar manifestations, such as, eye rolling up, slanting neck, backward neck tilt, facial distortion, etc. 2. Inability to sit still: appears in 1~2 weeks of treatment. Walking back and forth, emotional anxiety or unpleasantness, uncontrollable agitation, inability to sit still, repeatedly walking, stepping in place, etc. 3.Parkinson’s disease: appears 1~2 months after treatment. Motor inability, high muscle tone, tremor, autonomic dysfunction. Initially, there is hypermobility and increasingly smaller writing. In severe cases, there is loss of coordinated movements, rigidity, rickety posture, panic gait , mask raising face, coarse tremor, salivation, and seborrhea. 4, delayed dyskinesia: Most often seen after several years of continuous application. Characterized by involuntary, rhythmic stereotyped movements. The severity fluctuates, disappearing during sleep and increasing during emotional excitement. The earliest is a slight tremor around the tongue or mouth and lips. Pharmacogenic extrapyramidal reactions are particularly common in clinical practice. A variety of commonly used drugs have side effects that cause extrapyramidal reactions, such as finasteride, cough suppressant, atropine, gastrofacial, metronidazole, cimetidine, chlorpromazine, fenarizine, and flunarizine hydrochloride (Cipro). All these drugs can produce extrapyramidal excitatory effects to some extent and can lead to dysregulation of the central nervous system control of the extrapyramidal system, making the extrapyramidal system excitatory, as a result of which the muscle force and muscle tension controlled by the extrapyramidal system are out of control, thus causing a series of signs and symptoms related to muscle force and muscle tension. Extrapyramidal symptoms such as drowsiness, weakness, sluggish expression, muscle tremor, slanting neck, swallowing disorder, inability to sit still, etc. may occur. The key is to follow the doctor’s instructions and not to increase the dose of medication easily, and not to buy medication at will. If abnormalities occur, you should contact your doctor in a timely manner.