Questions related to the long-term use of antibiotics

  Today I saw some parents in this forum saying that their children have been taking antibiotics for a long time and the frequency of colds has increased and some babies have diarrhea. Then let’s try to minimize this harm. I deliberately googled the explanation of “antibiotics” and its role and side effects, the results are as follows: 1, the term explanation: antibiotics (antibiotics) is produced by microorganisms (including bacteria, fungi, actinomycetes) or higher plants and animals in the process of life with anti-pathogens or other activity of a class of Antibiotics are a class of secondary metabolites produced by microorganisms (including bacteria, fungi, actinomycetes, and higher plants and animals) that have anti-pathogenic or other activities and can interfere with the developmental functions of other living cells. The antibiotics now in common clinical use are extracts from microbial culture fluids and chemically synthesized or semi-synthesized compounds. There are no less than 10,000 known natural antibiotics.  2, use: antibiotics used to be called antimicrobial, in fact it can not only kill bacteria and mold, mycoplasma, chlamydia and other disease-causing microorganisms also have good inhibition and killing effect, in recent years, usually renamed antimicrobial antibiotics as antibiotics. The antibiotics can be a substance produced during the growth and reproduction of certain microorganisms, used to cure the disease in addition to the direct extraction of antibiotics; there are completely synthetic or partially synthetic. In general, antibiotics are drugs used to treat various bacterial infections or inhibit the infection of disease-causing microorganisms.  3, toxic reactions: ① nervous system toxic reactions; aminoglycosides damage the eighth pair of brain nerves, causing tinnitus, vertigo, deafness; high dose penicillin G or semi-synthetic penicillin or cause neuromuscular blockade, manifested as respiratory depression or even respiratory arrest. Chloramphenicol and cycloserine cause psychotic reactions, etc.  ②Toxic reactions of hematopoietic system; chloramphenicol may cause repletion anemia; chloramphenicol, ampicillin, streptomycin and neomycin may sometimes cause granulocyte deficiency. Gentamicin, kanamycin, vincristine IV, V, VI can cause leukopenia, cephalosporins occasionally cause erythrocytes or leukocytes, thrombocytopenia, eosinophilia.  Hepatic and nephrotoxic reactions: Tobramycin may occasionally cause elevated transaminases, and most cephalosporins may cause transaminases, alkaline phospholipase I and II, polymyxins, aminoglycosides and sulfonamides may cause renal tubular damage at high doses.  Gastrointestinal reactions: oral antibiotics can cause stomach discomfort, such as nausea, vomiting, epigastric fullness and loss of appetite. Among the tetracyclines, especially chlortetracycline, doxycycline and dimethyltetracycline are significant. Among the macrolides, erythromycin is the most serious, while methomycin and spiramycin are less serious. Tetracyclines and rifampin can occasionally cause gastric ulcers.  ⑤ Long-term use of antibiotics can lead to the wrong killing of the normal probiotic flora in the body, resulting in intestinal disorders, resulting in a variety of intestinal abnormalities and adverse reactions. We can use Bifidobacterium bifidum Lactobacillus triplex tablets to replenish the normal probiotic flora in the body which is killed by antibiotics, so as to avoid the abnormal intestinal function and adverse reactions caused by intestinal disorder caused by taking antibiotics.  (6) Antibiotics can cause dysbiosis and vitamin B and K deficiency; they can also cause secondary infections, such as pseudomembranous enteritis, acute hemorrhagic enteritis, Candida infection, etc. Pseudomembranous enteritis caused by lincomycin and clindamycin is the most common, followed by vanguardycin IV and V. Acute hemorrhagic enteritis is mainly caused by semi-synthetic penicillin, with ampicillin causing the most chances. In addition, long-term oral high-dose neomycin and application of kanamycin cause degenerative changes in the intestinal mucosa, leading to malabsorption syndrome, causing diarrhea and long-term weight gain in infants, which should be preoccupied. A few people with antibiotics cause anal itching and perianal erosion, the symptoms can disappear after stopping the drug.  (7) Allergic reactions to antibiotics are generally divided into anaphylaxis, serum sickness-type reactions, drug fever, rash, angioneurotic edema and allergic myocardial damage, etc.  (8) The after-effects of antibiotics refer to the after-effects of discontinuing the drug, such as permanent deafness caused by streptozotocin. Many chemotherapeutic agents can cause “triptogenic” effects. The rate of teratogenicity of rifampicin is 4.3%, and chloramphenicol, ashwagandha and some antitumor antibiotics have mutagenic and carcinogenic effects.  After using antibiotics, it is best to supplement probiotics Children using antibiotics have a greater impact on the gastrointestinal tract. This is because under normal conditions the human intestine hosts many species of bacteria that make up the normal flora. 90% of the normal flora are resident bacteria, mainly E. coli, Bifidobacterium, etc.; 10% are passerine bacteria, including E. coli, Aspergillus, Pseudomonas aeruginosa and Staphylococcus, etc. The beneficial bacteria and harmful bacteria in the intestinal tract are mutually restrained and coordinated to maintain the micro-ecological balance, but also to block the invasion of foreign attack bacteria, thus maintaining the health of the body.  But antibiotics do not grow eyes like people, sterilization often good and bad through kill. As sensitive bacteria in the normal flora are inhibited or killed, drug-resistant bacteria such as staphylococcus lose resistance and restraint from other bacteria and take advantage of the opportunity to multiply, causing disruption of the intestinal bacterial flora. The child also suffers from loss of appetite and decreased immunity. Infant and toddler experts remind parents not to panic when their children experience the above symptoms, but to take probiotic supplements to regulate the intestinal flora of their children and restore the ecological balance of the intestinal flora.  In order to strengthen the child’s immune system, so that the impact of antibiotics on children to reduce some, I am ready to give the baby during the medication on children’s protein powder and probiotics, I hope to play a role, so that the treatment effect can also be faster and better, the child is sick (cold, etc.) will make the adenoids and increase, so that the original effect discounted, affecting the treatment process, so mothers can also try.  May the children be healthy soon!