The treatment of premature ejaculation mainly includes oral medication, psychotherapy, and topical anesthetics and so on. 1. Oral drug treatment mainly includes 5-HT reuptake inhibitors, such as dapoxetine. These drugs can increase the concentration of 5-HT in the center to prolong the ejaculation time. Contraindications include severe cardiovascular and cerebrovascular disease, recent stroke, low blood pressure, severe liver damage, and is contraindicated in minors. 2. Psychotherapy is mainly to help men correct their own misconceptions about sex, eliminate their anxiety, etc., so that they can prolong ejaculation time and restore their self-confidence in sex. 3. Topical anesthetics are mainly lidocaine sprays, etc., aimed at prolonging the ejaculation latency period. Contraindications include severe hepatic or renal dysfunction, heart failure, conduction block and so on. Once the symptoms of premature ejaculation, to avoid self-medication, should immediately go to the hospital for consultation, under the guidance of the doctor reasonable use of drugs.