The number of times a boil can be changed without pain is generally based on factors such as whether the boil is co-infected, the size of the boil volume, and its own different tolerance to pain. If the size of the boil is very small, there is no acute inflammation such as redness, swelling, heat and pain, and the tolerance to pain is strong, the pain can be relieved after 2-3 times of topical application of Ruyi Jinhuang Ointment, which will not cause serious complications. Second, if the boil is larger in size, with local acute inflammation such as redness, swelling, heat and pain, and abscess formation, and the patient’s tolerance for pain is poor. In this case, it is necessary to fully drain the pus and take a longer time to change the medication. Generally, it takes 5-6 times to change the medication before the local granulation tissue can proliferate faster and the pain symptoms can gradually disappear and subside.