Intracranial infections are mainly due to the invasion of bacteria, viruses, and fungi into the central nervous system through direct or indirect routes, thus threatening the patient’s health and leading to a significant decrease in quality of life. Different pathogens can cause different degrees of damage to brain tissue, and most patients are associated with high fever, coma, impaired consciousness, limb paralysis, speech impairment, cognitive impairment, and dementia. If treatment is not performed in a timely manner, as the patient experiences a dramatic increase in intracranial pressure, it leads to brain herniation, confusion, seizures and respiratory and cardiac arrest, and even death. For intracranial infections with a history of brain hemorrhage or craniotomy for traumatic brain injury, further examination is needed to identify the specific cause or possible factors of the infection and to know the site and area of the infection. How to check for intracranial infection? This involves the diagnostic criteria for intracranial infection. In the cerebrospinal fluid department guidelines 1, there are clinical signs and symptoms of intracranial infection such as high fever, headache, and neck tonicity; 2, white blood cell WBC>0.01X109/L in cerebrospinal fluid examination, with an increase in multinucleated cells predominating. Sugar <2.25 mmol/L, chloride <120 mmol/L, protein >0.45 g/L; 3, positive results of cerebrospinal fluid bacterial culture; 4, a definite cause of infection, such as cerebrospinal fluid leakage. Anyone who has the 3rd article can confirm the diagnosis, such as a negative bacterial culture of cerebrospinal fluid needs to be combined with the rest of the articles. Through detailed examination and diagnosis, light cases can be controlled and improved by drug treatment. In heavy cases, it is obvious that conventional anti-infective treatment is not sufficient. Many patients, although treated early, have unsatisfactory results due to incorrect choice of modalities, and may even have more serious consequences that endanger the patient’s life. Therefore, for patients with intracranial infections, they must go to a regular hospital for standardized treatment in a timely manner, and they should take drugs in compliance with medical advice. In addition, it is usually necessary to strengthen their resistance to reduce the risk of infection.