Plastic surgeons have to answer this question to their patients over and over again every day. For most moles, a glance is enough to decide whether to cut or not; others have to be treated with caution, otherwise a lifetime of fame will inevitably be put into water, and the white earth will be a good clean. So first of all, what is a mole? There are various types of moles and different ways of naming them. To put it simply, they are benign skin tumors composed of melanocytes, which can be distributed anywhere in the body, but tend to occur on the face and neck. When we see a mole, both doctors and patients consider it from two aspects: first, does it affect the beauty, and second, is it malignant? Because moles are mostly found on the face and neck, they inevitably become unique signs of individuals, which may have aesthetic significance, such as beauty moles and peach blossom moles; or they may have “facial science” significance, such as the “great man’s mole” on the left side of the middle of the chin, the “prosperous husband’s mole”, and so on. The above are good meanings. Unfortunately, more often than not, moles play the role of destroying facial aesthetics and facial features, causing some psychological burdens to aspiring men and women, and even destroying good interpersonal relationships, causing problems in employment and choosing a spouse. Then, this kind of removal based on improving the aesthetics of the appearance is necessary. Another factor that influences our decision is whether the mole is malignant or not and whether it will become malignant in the future. We first need to know how a mole can affect our health if it is malignant. From this perspective, we can divide malignant moles into two categories: one is squamous cell carcinoma and basal cell carcinoma, which are skin cancers with high incidence but relatively low malignancy, and most of them can be cured by surgical excision, and only a very small proportion of advanced skin cancers may bring fatal danger; the other is melanoma, which is an extremely malignant tumor, and viewers who have seen “Do Not Disturb” may The other type is melanoma, which is a highly malignant tumor, and viewers who have watched “The Non-Stop” may still have the impression that the character played by Sun Honglei is suffering from a small plantar mole transformed into melanoma. Although the treatment of melanoma has made a lot of progress, most of them have progressed to stage 4 by the time they are discovered due to poor medical awareness in China, with mortality rates as high as 70% to 90% and life expectancy of only a few months to a year or two, while stage 1 melanoma has a 5-year survival rate of 94% and a very high cure rate, so early detection and treatment is especially important. Therefore, for cutting or not cutting a mole, our main consideration is whether it will become malignant into melanoma. The good thing is that there are still some clues that doctors can pursue and make an evaluation and diagnosis, and it is important to emphasize that early diagnosis is equal to saving lives. However, not all patients have easy access to a doctor at all times, and moles change throughout their lives, so self-examination is especially important. Now I would like to introduce the methods of self-examination, first of all, the ABCDE principle: A (asymmetry): that is, asymmetry. If the appearance of a mole is not centrally symmetrical, which means that the mole cells are growing outward asymmetrically, then it may have malignant changes. B (border): i.e. the border is irregular, like the border of a map, the edges are intertwined, which also means the mole cells are growing outward irregularly. C (color): i.e. color change, the color of the mole deepens or becomes lighter, or presents different shades, the middle is dark and the edge is light; or first becomes darker and then fades to lighter. This is often seen when malignant melanocytes are in the process of rapid growth and autoimmune cells are killing them. D (diameter): i.e., the size of the diameter, moles with a diameter greater than 5-6 mm have a high possibility of malignant transformation. E (enlargement or evolvement): i.e., becoming larger or progressing. If the mole becomes larger than 5mm, or one of the changes in the above points, it is a precursor of malignant change only, and should seek medical attention in time. Secondly, in the yellow race, melanoma tends to occur at the end of the limbs (42%), so special attention should be paid to moles occurring in the hands and feet, and another part occurs in the mucous membranes (23%), so moles in the mucous membranes such as the mouth, lips, and genital tract should not be taken lightly. Therefore, it is up to the patient to consider whether to cut moles that affect aesthetics, and for moles with risk of malignant transformation, doctors recommend early removal for pathological examination.