Jaundice is a condition in which the skin and sclera become yellow in color due to elevated bilirubin in the blood. Treatment of this condition is primarily a matter of treating the diseases that cause jaundice. These diseases include liver damage, biliary obstruction, hemolytic changes in the blood system, and some unsafe medications, and treatment for jaundice caused by various diseases varies. Diseases caused by liver injury are mainly diseases that occur in the liver itself, and are more commonly seen in various types of hepatitis, cirrhosis, and other diseases. For these diseases, the main treatment is to protect the liver. As the liver function returns to normal, jaundice can gradually decrease or subside. Biliary obstruction is another type of disease that causes jaundice, mostly due to gallstones or bile duct tumors blocking the bile ducts, resulting in jaundice. For gallstones, surgery is usually required to remove the bile duct stones and restore the bile duct. In the case of biliary tumors, the bile duct segment with the tumor is removed and the bile duct is anastomosed to the intestine to allow the bile to drain directly into the intestine. A hemolytic reaction in the blood system can cause excessive destruction of red blood cells, resulting in jaundice. This type of jaundice requires treatment with blood replacement therapy in some cases depending on the treatment of the primary disease. For hemolytic jaundice caused by abnormal red blood cell morphology, sometimes a splenectomy is required to cure the jaundice by reducing the destruction of red blood cells. There are drugs that can themselves cause jaundice due to impaired bilirubin metabolism. In this case, the primary treatment requires prompt discontinuation of the drug causing the jaundice, followed by liver protection therapy. The jaundice will gradually return to normal as the drug is completely metabolized. In a small number of patients, mild jaundice is caused by low function of enzymes involved in bilirubin transport and metabolism in the liver. On examination, total bilirubin or direct or indirect bilirubin is found to be mildly elevated, while other tests of liver function such as transaminases, transpeptidases and alkaline phosphatase are normal, and the patient is not in any discomfort. Most of these cases do not require treatment. Jaundice is complicated by the fact that there are many diseases that can cause it. The main principle of treatment is to first identify the cause of the disease and to treat it according to the different diseases.