It was first reported in 1819 by Barrata as a rare and severe congenital malformation. 1. It is usually bilateral and is usually inherited as an autosomal anomaly. 2. The pupillary margin is almost exactly equal to the corneal margin, and the equatorial part of the lens is visible. The residual iris of the atrial angle is visible under the atrial angle lens. 3, often accompanied by nystagmus, congenital cataract, amblyopia, refractive abnormalities, corneal clouding, glaucoma, etc., may also be combined with other developmental abnormalities in the body such as Wilms’ tumor, mental retardation. 4, vision loss: mainly amblyopia caused by macular central sulcus dysplasia, but also may be combined with glaucoma, cataract, corneal clouding and other causes .