The clinical manifestation of coma is the loss of the wakefulness-sleep cycle, and the patient is in a continuous deep sleep and cannot wake up. The patient’s perception, attention, thinking, emotion, orientation, judgment, memory and many other mental activities are all lost. The patient does not understand himself or the external environment and does not respond to external stimuli. The patient is unable to perform simple commands. When given a strong painful stimulus, there is no conscious response at all, except for sometimes painful expressions or moans. Prevention of loss of waking state Removing the cause of the disease is the most crucial, and it is important to pay attention to the neurology department of a regular hospital to determine the specific treatment measures under the personal diagnosis of an experienced physician, and it is necessary to adhere to the treatment. Regular checkups are still necessary.