Cholesteatoma of external auditory canal is caused by inflammatory stimulation, trauma and other causes of keratinized epithelial shedding accumulation in the external auditory canal, need to use surgery to remove the cholesteatoma, and after infection can use cephalosporins, quinolones and other antibiotics to control infection. 1. Surgical treatment: commonly used surgical treatments include otorhinoplasty, mastoidectomy, tympanoplasty and so on. 2. Antibiotic medication: When inflammatory infection occurs, cephalosporins, quinolones and other antibiotics are needed to control the infection, such as cefadroxil, ceftazidime, ceftriaxone sodium, levofloxacin, ciprofloxacin and so on, which play a role in controlling the acute infection and improving the inflammatory symptoms. Adverse reactions such as nausea, vomiting, allergy, skin irritation, muscle damage, etc. can occur with these drugs above, and systemic use of quinolones is prohibited under 18 years of age. When using these medications, be sure to use them under a doctor’s supervision.