Not necessarily, jaundice is a sign of hyperbilirubinemia. Increased production or decreased metabolism of bilirubin in the serum can cause jaundice. In addition to the cause of biliary stasis, massive destruction of serum red blood cells leads to increased unconjugated bilirubin, which exceeds the uptake capacity of the liver and can lead to haemolytic jaundice.
Hepatocellular jaundice can also develop as a result of damage to hepatocytes, leading to a decrease in their ability to take up unconjugated bilirubin and a slowing of the excretion of conjugated bilirubin.
In addition, congenital enzyme deficiencies resulting in abnormal uptake, conjugation and excretion of bilirubin by the body can also lead to jaundice.