Female nipple long nevus may be a normal pigmented patch; however, if there is itching, pain or local trauma, etc., we need to be vigilant about its malignant transformation and becoming melanoma. Nevus is a pigmented patch, which can be divided into intradermal nevus, junctional nevus or mixed hemorrhoids. Generally, the surface of intradermal nevus is smooth, and there can be sweaty hair, which is less likely to be malignant. Junctional nevus is darker in pigmentation, and the nevus cells are easily provoked, and can become malignant in case of local infection or trauma. Mixed hemorrhoids, i.e. intradermal nevus and junctional nevus exist at the same time. When the nevus becomes bigger, deeper pigmented, itchy or painful, there is a possibility of malignant transformation, and when there is bleeding or rupture present, it is more important to be vigilant and check whether it is malignant. At the same time, it is recommended that patients with moles on the nipple should avoid excessive stimulation and rubbing of the moles to prevent cancerous changes. If there is any change or discomfort in the moles of female breasts, it is recommended to consult a specialist in the hospital in time to make a clear diagnosis, and treat it as early as possible if it is malignant.