What are dermal fillers? What are the conditions of allergy? Dermal fillers are gel-like substances that can be injected intradermally or subcutaneously, mainly for repairing depressed deformities on the face or body surface, aging facial depressions or static wrinkles, in addition to beautifying the features and adjusting the contours of the face or body. There are various types of injectable fillers, which can be broadly classified into three categories: animal origin, human tissue origin and artificial synthesis according to their sources. Although injectable fillers are strictly screened and prepared, the compatibility of materials and human tissues is usually good, and allergic reactions are relatively rare. However, when certain materials containing or having antigenic substances are injected, or when the injected object is sensitive to certain materials, local allergic reactions will occur, and in extreme cases, serious allergic reactions, such as anaphylaxis, can even be life-threatening. Therefore, allergy is one of the problems that cannot be ignored in the field of cosmetic injections. How do allergies to injectable materials occur? Why do people become allergic? Injectable allergy is mostly a type I allergic reaction, which usually manifests as a rash. It is believed that the occurrence of this allergic reaction is directly related to IgE in the serum. Under the stimulation of antigen, B lymphocytes are transformed into plasma cells and produce IgE, which can bind to basophils in peripheral blood and IgE receptors on mast cells, putting the body in a sensitized state. This state can be maintained for six months to several years, and then gradually disappears if there is no stimulation by the same antigen. When the same antigen (such as the injected material) enters the body again, it forces the cells to release basophilic granules, which in turn release active substances such as histamine and 5-hydroxytryptamine, resulting in allergic reactions such as smooth muscle spasm, capillary dilation, increased vascular permeability, and increased glandular secretion, causing symptoms such as rash, skin flushing, gastrointestinal discomfort, and respiratory distress. How do I know if I am allergic? What will be the reaction if I am allergic? Allergies caused by injectable materials are usually localized and relatively mild. It mostly manifests as swelling, redness or rash of the skin near the injection area; for severe allergy, it manifests as shock, hypotension, respiratory distress, laryngeal edema, and generalized urticaria. Why am I allergic? No one I injected with is allergic For dermal fillers that require allergy testing, an allergy test must be performed. So what materials are more likely to be allergic? In fact, it is the allergy probability of various injectable materials + your own body type that determines the size of the risk of allergy occurrence. It has been reported in the literature that the allergy probability of collagen is 1~3%, while that of hyaluronic acid is 0.1%, which needs to be mentioned that hyaluronidase, itself, is a protein preparation, so: there is a possibility of allergy! Therefore, for safety reasons, hyaluronidase needs to be skin tested before use. What should I do if I have an allergy? What do I need to pay attention to in the future? So what should I do once an allergy has occurred? Some patients complain that they have become big red faces or have bumps for three days since the foreign body was injected, so how can I get rid of it completely? What all do I need to pay attention to? The treatment of skin allergies is still at the conservative stage, and frankly, I don’t have a particularly effective solution. My treatment principle is that for mild localized allergies, symptomatic treatment can be used: 1. Oral antihistamines – Mindy, Keratan. 2, local rash – you can use topical stove glycol lotion. 3, those with abdominal pain, diarrhea and other gastrointestinal reactions – antispasmodic and analgesic drugs, atropine. 4, there are respiratory symptoms – anticholinergic drugs, etc.; for relatively serious patients, or the acute phase of the onset of the disease can be given glucocorticoids orally or intravenously; for serious cases need to follow the steps of anaphylaxis rescue treatment. Once an allergic reaction has occurred and has recurred, you need to pay attention to your diet and living habits before getting rid of the allergen completely: eat a light diet, avoid greasy and spicy food, stay away from smoking and alcohol, and avoid overheated environments. Some people say how they can’t remember what to do? Then please remember one, the food and environment that can make you blush, you should try to stay away! It is also important not to touch the substance that makes you allergic again, for example, people who are allergic to hyaluronic acid should not try to inject it repeatedly.