Left anterior chest above the subclavian pain chest tightness may be related to pleurisy, intercostal neuritis, myocardial infarction, etc., mainly through the drug and surgical treatment, the use of drugs should follow the doctor’s instructions. 1. Pleurisy: it can be manifested as chest pain, chest tightness, cough, sputum and dyspnea, etc. The nature of chest pain is stabbing or pulling pain. Tuberculous pleurisy requires regular anti-tuberculosis treatment, such as the use of isoniazid, rifampicin and so on. Sensitive antibiotics, such as cefdinir, may be used for pleurisy caused by bacterial infection. The condition requires surgical treatment, including fiber foci adhesion release surgery, closed chest drainage, etc. 2. Intercostal neuritis: Typical symptoms are pain distributed from posterior to anterior along the nerve course. Non-steroidal anti-inflammatory drugs, such as ibuprofen, can be used if the pain is severe. Surgical excision method is mainly used for intercostal neuritis caused by tumor, sternal trauma, etc. 3. Myocardial infarction: caused by imbalance of blood supply to the heart, manifested by intense chest pain, accompanied by nausea, vomiting, profuse sweating and tachycardia and other symptoms. Therapeutic drugs include analgesics such as pethidine, anticoagulants such as common heparin, and antiplatelet drugs such as aspirin. It can also be treated with surgery such as percutaneous coronary intervention. Left anterior chest above the subclavian pain chest tightness can also be seen in other diseases, it is recommended that patients seek medical attention in a timely manner, so as not to delay the condition.