It is the most common benign neoplasm of the nasal region with a non-squamous epithelial origin. Nasal pleomorphic adenomas occur in the nasal septum (bony and/or cartilaginous) and the lateral wall of the nasal cavity, while sinus pleomorphic adenomas are extremely rare. The age of onset ranges from childhood to 90 years, with an average age of 42 years, and the incidence is approximately equal in both sexes. The tumor is round or oval in shape with a diameter ranging from 0.5 to 7 cm, with an envelope and a smooth or nodular surface. Microscopically, the tumor was composed of a mixture of glandular epithelial cells, myoepithelial cells, and mucus-like or cartilage-like mesenchyme. The tumor cells were arranged in sheets, irregular cords or adenoidal ducts, with cuboidal, polygonal or spindle-shaped cells and uniformly sized nuclei, without nuclear fission phase or degenerative development. The tumor parenchyma and mesenchyme are poorly defined. Nasal mixed tumors are characterized by a high cellular component and a low stromal component. Etiology and pathogenesis of mixed nasal tumors Nasal mixed tumors originate from the mucous glands of the nasal mucosa or ectopic salivary glands, and are also thought to originate from the Jacobson plow nasal organ in the lower anterior part of the nasal septum. The diagnosis of mixed nasal tumors is not difficult based on history and physical examination, combined with imaging, but pathological examination is the basis for confirming the diagnosis. Differential diagnosis Mixed tumors should be differentiated from involuted papilloma, nasal polyp, purulent granuloma, chondrosarcoma, and adenoid cystic carcinoma. Clinical manifestations The tumor grows slowly and has a long course. Self-perceived symptoms are mainly progressive nasal congestion on one side, but there may also be nasal bleeding, runny nose, loss of smell, local bulging, etc. If the tumor increases and invades the surrounding sinuses and orbits or originates from the external nose and sinuses, there may be deformities of the external nose, cheeks and palate, headache, tinnitus, hearing loss, lacrimation, diplopia, eye displacement, proptosis, etc. On physical examination, the tumor is polyp-like, grayish-red in color, with a nodular, broad-based surface, or appears as a submucosal mass, moderately hard and slightly elastic to touch. x-ray film or CT scan can help determine the size, location and invasion range of the tumor. Overview of nasal hybrid tumor treatment Surgical treatment After diagnosis, different surgical methods should be adopted to completely remove the tumor according to the size and location of the tumor, such as nasal septal resection, turbinate resection, lateral nasal dissection, maxillary sinus radical resection and so on. The tumor should be removed as completely as possible to avoid damaging the envelope and causing recurrence by overflowing the tumor tissue for implantation.