Among the causes of premature ejaculation, psycho-spiritual factors are the most common causes, and clinical treatment is also based on psychotherapy. At present, psychotherapy, especially behavioral therapy, is highly recommended at home and abroad. General psychotherapy includes: teaching patients about sex, helping them to relieve their worries and reduce anxiety and tension, and teaching them to master the method of muscle relaxation to eliminate fear and anxiety before sexual intercourse. Among behavioral therapies, homework therapy is commonly used clinically, which requires patients to complete it in quality and quantity. It is divided into 7 steps: mutual touching of sexually sensitive areas, establishment of excitement of female organs, sensation of arousal of penis, prolongation of penile excitement, sensation of sexual organs when they are in contact, sensation of clitoral stimulation after penis enters vagina, and sensation of sexual excitement. It is important to note that the treatment of premature ejaculation is a matter for both husband and wife, especially the participation of the wife in the treatment is very important. The psychological treatment of premature ejaculation should obtain the cooperation of the patient’s wife. The misunderstanding or complaint of the female partner will make the male partner’s tension and anxiety rise, which will in turn increase the psychological burden and enter a vicious circle. The female partner should have a sympathetic and caring attitude, give words and behavioral comfort, relieve the male partner’s tension and help him to establish confidence in healing. For premature ejaculation caused by organic lesions, clinical treatment is mainly aimed at the primary cause. Therefore, in the treatment of premature ejaculation, we should not only consider the choice of medication, but also psychotherapy and behavioral therapy. At the same time, we should pay attention to the cooperation of both husband and wife is also an important factor in the treatment.