Syphilis has been growing rapidly in China in recent years and has become the STD with the highest number of reported cases, and the number of reported cases of congenital syphilis is also increasing. Syphilis is a disease unique to humans and is a chronic systemic infection caused by the syphilis spirochete. It can cause damage to multiple systems and organs of the body, resulting in a variety of clinical manifestations, leading to tissue destruction, malfunction, and even life-threatening conditions. Syphilis transmission 1, syphilis can be transmitted horizontally through sexual contact; 2, blood-borne transmission: dominant and recessive syphilis patients are the source of infection, the skin lesions of people infected with syphilis and their secretions, blood contains syphilis spirochetes; 3, placental transmission: if a pregnant woman is infected with syphilis, during pregnancy can be transmitted to the fetus through the placenta, causing intrauterine infection in the fetus, which can lead to miscarriage, premature birth, stillbirth or delivery Fetal transmission of syphilis. It is generally believed that the earlier the stage of syphilis in pregnant women, the greater the chance of infection of the fetus; 4, the birth canal transmission: when the fetus passes through the birth canal infected with syphilis, the syphilis spirochetes in the birth canal area can be infected to the fetus, resulting in the onset of syphilis infection in the newborn; 5, indirect contact transmission. Mother-to-child interruption of syphilis Premarital and prenatal syphilis screening are two important lines of defense to prevent congenital syphilis. 1. Pregnant women should be routinely screened for syphilis serology at an early stage or at the first maternity visit. Those who are positive should be given regular and adequate anti-syphilis treatment. (1) Syphilis found at <28 weeks of pregnancy can be prevented by regular and adequate anti-syphilis treatment; (2) Syphilis found in late pregnancy can be treated to reduce the incidence of congenital syphilis. (2) All infants born to syphilis-infected mothers should undergo quantitative non-syphilis spirochete serological testing and be treated and followed up accordingly. Diagnosis of congenital syphilis 1.Titer greater than 4 times the mother, regardless of the presence of clinical symptoms; 2.Titer less than 4 times the mother, with clinical symptoms of syphilis infection, given standardized treatment and follow-up, at 18 months of age for monitoring of syphilis spirochete antigen serology test, positive reaction; 3.Titer less than 4 times the mother, no clinical symptoms, given preventive treatment, every 3 months for syphilis spirochete antigen serology 4. not turned negative at 6 months of age, always maintained at low titer level, monitored by syphilis spirochete antigen serology test every 3 months, still positive after 18 months. Breastfeeding advice for mothers with syphilis 1. Breastfeeding can be done when the mother has implemented maternal-infant interruption during pregnancy, except for congenital syphilis and the mother has given regular anti-syphilis treatment, and the RPR titer has decreased more than 4 times or is below 1:2, without nipple cracking and mastitis; 2. Breastfeeding should be suspended if the mother has not undergone regular treatment or the titer is still high after treatment.